http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2726320-C1

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filingDate 2020-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9fa9914e01dbcca6072fdc423d0beae
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publicationDate 2020-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2726320-C1
titleOfInvention Method for determining omeprazole impurity components
abstract FIELD: medicine. n SUBSTANCE: invention refers to medicine, mainly to pharmacology and pharmaceutical chemistry, and can be used for determining the admixture components of omeprazole. Disclosed is a method of determining the amount of impurities in reversed-phase high-performance liquid chromatography. Method consists in sample preparation consisting in sample dissolution with subsequent chromatography. Analysis is carried out using a chromatographic column with octodecylsilica gel (C18) and a mobile phase consisting of acetonitrile-isopropanol-water of deionised-orthophosphoric acid in ratio of components (35:15:45:5). Detection is carried out in amperometric detection conditions using a glass-carbon sensor with an operating voltage of 0.85 V. Chromatogram is recorded for 15 minutes. n EFFECT: method provides higher accuracy and rapidness of analysis when determining omeprazole impurity components. n 1 cl, 1 tbl, 1 ex
priorityDate 2020-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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