abstract |
FIELD: biotechnology. n SUBSTANCE: present group of inventions refers to immunology. What is presented is an anti-protein-1 antibody programmed cell death (PD-1) or its antigen-binding fragment, as well as a coding nucleic acid, a vector containing said nucleic acid, an isolated cell transformed with said vector, a method of producing said antibody or its antigen-binding fragment and a composition thereof for preventing or treating cancer. n EFFECT: antibody according to the invention is able to bind to PD-1 and inhibit its activity, therefore it is applicable for development of immunotherapeutic agents against various diseases associated with PD-1. n 11 cl, 23 dwg, 16 tbl, 13 ex |