| abstract |
FIELD: medicine. n SUBSTANCE: group of inventions refers to an antibody or its antigen-binding fragment, which specifically bind to human OX40L (hOX40L) and inhibit binding of hOX40L to human OX40 (hOX40). Group of inventions also relates to use of said antibody in producing a drug for treating or preventing OX40L-mediated disease or condition; a method of treating or preventing an OX40L-mediated disease or condition in a subject, comprising administering to a human a therapeutically effective amount of said antibody or fragment thereof; combination for treating or preventing an hOX40L-mediated disease or condition containing said antibody or antigen-binding fragment thereof and an additional therapeutic agent, selected from an mTOR inhibitor and an immunosuppressant which modulates IL-2 signaling; kit for treating or preventing hOX40L-mediated disease or condition in humans. n EFFECT: group of inventions provides treating or preventing the hOX40L-mediated disease or condition in humans. n 33 cl, 9 ex, 7 dwg, 6 tbl |