| abstract |
FIELD: medicine. n SUBSTANCE: invention relates to a method for treating breast cancer, involving administering a neoadjuvant therapy to a patient with HER2-positive, operable, locally advanced or edematous-infiltrative breast cancer, involving simultaneous administration of a combination of T-DM1 and pertuzumab, wherein said combination is administered in the absence of chemotherapy; removal of said breast cancer by radical surgery; as well as administering to the patient adjuvant therapy comprising simultaneous administration of a combination of T-DM1 and pertuzumab, wherein said combination is administered in the absence of chemotherapy. n EFFECT: invention provides treating breast cancer in a patient with HER2-positive, operable, locally advanced or edematous-infiltrative breast cancer. n 16 cl, 6 dwg, 5 tbl, 1 ex |