abstract |
FIELD: medicine; pharmaceuticals. n SUBSTANCE: present invention relates to immunology. Disclosed are an antibody or antigen-binding fragment thereof, specifically binding CD20. Also disclosed is a nucleic acid, an expression vector, a host cell and a method for producing a host cell. Also described is a method for producing the antibody, a pharmaceutical composition, a pharmaceutical combination, an inhibition method, a method of treating and using the antibody. n EFFECT: present invention can find further application in therapy of various diseases or disorders mediated by CD20, particularly oncological and autoimmune diseases. n 36 cl, 17 tbl, 27 ex, 38 dwg |