| abstract |
FIELD: pharmaceuticals. n SUBSTANCE: invention relates to compounds—selective androgen receptor destructors (SARD), represented by structure of formulas I and VII. In formula, I T is OH; Z is CN; Y is CF 3 ; R 1 is CH 3 ; R 2 is hydrogen, C 1 -C 12 -alkyl; Q 1 , Q 4 and Q 5 are each independently selected from hydrogen, CN; Q 2 and Q 3 each represent hydrogen or phenyl substituted with halogen; where at least two Q 1 , Q 2 , Q 3 , Q 4 and Q 5 are not hydrogen; or Q 2 and Q 3 are bonded together to form unsubstituted C 5 -C 8 -carboxyclic ring. In formula VII, T denotes OH; Z is CN; Y is CF 3 ; R 1 is CH 3 and Q 1 is F, Cl, Br, I. Invention also refers to specific compounds of said formulas and a pharmaceutical composition containing them. n (I) n (VII). n EFFECT: selective androgen receptor destructive ligands (SARD) and methods for use thereof are disclosed. n 15 cl, 8 tbl, 12 ex, 12 dwg |