| abstract |
FIELD: medicine. n SUBSTANCE: group of inventions relates to biomedical technology, specifically to a medical hydrogel for haemostatic assistants, products for preventing air leaks from the lungs or for preventing leakage of cerebrospinal fluid and antiadhesion products, to a combination for preparing a medical hydrogel, a method of producing a medical hydrogel, a kit for producing a medical hydrogel and use of a medical hydrogel in products for preventing leakage of cerebrospinal fluid. Medical hydrogel and a combination for preparing a medical hydrogel comprise a mixture of a first component - ε-polysin and/or poly-L-lysine, and polyethyleneimine and a second component - one or more of 4-branched polyethylene glycol-succinimidyl gllurate, 4-branched polyethylene glycol-succinimidylsuccinate and 4-branched polyethylene glycol-succinimidylcarbonate, wherein polylysine has a degree of polymerisation of 20 or more. Method of producing a medical hydrogel involves dissolving a first component in a first buffer solution to produce a first mixed solution, dissolving the second component in a second buffer solution to obtain a second mixed solution, mixing the first mixed solution and the second mixed solution to obtain a medical hydrogel. Kit for producing a medical hydrogel contains a combination for preparing a medical hydrogel and a buffer solution for dissolving each component of the combination. n EFFECT: group of inventions provides good biocompatibility, low degree of swelling, good biodegradability of the medical hydrogel and absence of irritant action on tissues. n 18 cl, 11 dwg, 7 tbl, 11 ex |