http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2723509-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25a6289b957369e15597b9b73392417e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M1-02 |
| filingDate | 2019-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be2378fd225e17a1df7c412c880c99a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20b5fda19c2d8bf29765c5604be88c62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1479c2a9aadb597b30d368de3f021160 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c51398a20c9cc393c44eaad7376d20a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9792e481e0822ddbee438d7ca80164f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06d0b4c32ee4b60adc1374f2fd73ebf4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf7611e1b7f7057d45c869f3840c914c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d704434916e713dd702aa3c1b3f5e7b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dbe82de29a49ee5a1897a1806416cc6 |
| publicationDate | 2020-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2723509-C1 |
| titleOfInvention | Method for myocardium protection against reperfusion injuries in heart operations (embodiments) |
| abstract | FIELD: medicine. n SUBSTANCE: invention relates to surgery, in particular to cardiosurgery. Before heart cavity opening, carbon dioxide gas is fed through rotameter into cavity of opened pericardium with pressure of 0.2–0.4 MPa and volume rate of 2-3 l/min. Carbon dioxide is supplied during the whole main stage of operation, and stops after sealing of heart cavities and removal of clamp from aorta. Second embodiment of the invention involves: prior to removal of a clamp from the aorta, retrograde thermal blood perfusion is performed with an IC apparatus with addition of magnesium at rate of 200 ml/min for 2 minutes. In the perfusate of the IC apparatus, the following parameters should be achieved by this time: hematocrit - 25–30 %, Ca 2+ - 1.2–1.3 mmol/l, K + - 4.5–5.5 mmol/l, Hb - 90–100 g/l, glucose - norm, BE: + 2–3. After removal of a clamp from the aorta, complete IC with left ventricular unloading was continued. Duration of reperfusion depends on aortic clamping time and ranges from 15 to 25 minutes. Count is started after removing the clamp from the aorta and continued for not less than 10 minutes from the moment of restoration of the regular rhythm or the beginning of the temporary cardiac pacing. During this period cardiac preparations were not introduced. Reperfusion completion criteria are stable rhythm normalization, return of the ECG complex to the preoperative pattern, as well as adequate myocardial response to the volume load. n EFFECT: method enables reducing the frequency of use, dosage and the number of antiarrhythmic and inotropic preparations when disconnected from artificial blood circulation, minimizing the effect of damaging factors on the myocardium in the first minutes after the period of global ischemia, in order to prevent and restore the function of reversibly depressed cardiomyocytes. n 2 cl, 3 tbl |
| priorityDate | 2019-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.