| abstract |
FIELD: medicine.SUBSTANCE: invention relates to the field of medicine, namely to experimental pharmacology. Method of endothelial dysfunction correction in the ADMA-like model of preeclampsia involves reproducing a pre-eclampsia model in the Wistar rats daily from 14th to 20th day of pregnancy by the intraperitoneal introduction of L-nitro-arginine-methyl ether in dose of 25 mg/kg, characterized by the fact that for the purpose of endothelial dysfunction correction, acetylsalicylic acid is administered orally in dose of 10 mg/kg once day from 14th to 20th day of pregnancy.EFFECT: method provides marked correction of endothelial dysfunction with acetylsalicylic acid in conditions of a reproducible ADMA-like model of preeclampsia in pregnant rats.1 cl, 1 tbl, 1 ex |