Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33b011e77b33662b8bf1f2ff2de7b661 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2059 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
filingDate |
2016-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2020-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97d662812918a71f262a69eec4093b93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90bf0203e25bbe6bafa73448987b5011 |
publicationDate |
2020-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
RU-2720509-C2 |
titleOfInvention |
Combined therapy pac-1 |
abstract |
FIELD: medicine.SUBSTANCE: invention proposes combinations and methods for inducing cancer cell death. Combinations and methods for using them include using combinations for therapy in order to treat cancer and for selective induction of apoptosis in cancer cells. Combination comprises compound PAC-1 (2-(4-benzylpiperazin-1-yl)-N-[(2-hydroxy-3-prop-2-enyl-phenyl)methylideneamino]acetamide) in concentration of 4 mcM to 12 mcM and a second active ingredient which is a BRAF enzyme inhibitor having a mutation which is vemurafenib. Concentration of vemurafenib ranges from 0.5 mcM to 30 mcM. Combination also contains a pharmaceutically acceptable diluent, a filler or a carrier.EFFECT: combination of PAC-1 and vemurafenib shows synergistic anticancer activity and has less neurotoxic effects than the same amounts of other compounds and combinations of compounds, and can be effective in a specific cancer disease that has acquired resistance to previously used therapies.22 cl, 13 dwg, 1 tbl, 3 ex |
priorityDate |
2015-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |