| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb351a5a4e03ee3773bd0df5dbae9ac3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-498
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate |
2017-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae5b42164d8365c6e5f9fdec1f03ba72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dff19a29ca1a4ff8603a808b5a269b8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4972dd45232e5d31725605126317a3d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d72821b0fca6a2f8d2f5f62d2767bf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a3119d465b99e9cc57d512d8a0f4870
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59dcc6382a8e904f8ad1a0bbecdadba8 |
| publicationDate |
2020-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2718913-C1 |
| titleOfInvention |
Method of producing a compound for enhancing the cohesiveness of the complex substance trpv4-kca2.3 |
| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a method of producing a compound of formula (1). Method is carried out by reacting propane diamine with tert-butoxycarbonyl in dichloromethane at temperature from 0 to 25 °C, then obtained compound reacts with diphenylacetyl chloride to obtain corresponding amide. In the acidic conditions, the protective amine is removed from the protective tert-butoxycarbonyl group set at the first step of the process. Further, the obtained amine derivative undergoes amino-ether exchange with 4-quinazolone-2-carboxylic acid ester to form the desired compound of formula (1). n (1). n EFFECT: method of producing a compound of formula (1), which strengthens the degree of cohesiveness of the complex substance TRPV4-KCa2.3. n 1 cl, 5 dwg, 1 tbl |
| priorityDate |
2017-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |