| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da786794ff3b022e0c6a977ed30a76fa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18 |
| filingDate |
2016-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_beee73516a75f307add43c00cc4a1493
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf0b42496a05ab308634b6ed2afde1e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1667ab205c9f8f27cb1e701ef76fdd6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40f571276c02cbdbdb01c47ad9794cc8 |
| publicationDate |
2020-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2718058-C2 |
| titleOfInvention |
Synthesis method of rapamycin derivatives |
| abstract |
FIELD: chemistry; chemical or physical processes. n SUBSTANCE: invention relates to a method of producing a rapamycin derivative of formula (I), which involves preparing 2-(trisubstituted silyl)oxyethyl triflate by reacting ethylene oxide and tri-substituted silyl triflate, reaction of obtained 2-(trisubstituted silyl)oxyethyl triflate with rapamycin in the presence of a molar excess of the organic base and deprotection to obtain a rapamycin derivative—compound (I). n EFFECT: high output of end product. n 13 cl, 4 dwg, 5 ex |
| priorityDate |
2015-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |