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publicationDate 2020-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2716753-C1
titleOfInvention Method for simulating typhoid on small laboratory animals with artificial immunosuppression
abstract FIELD: medicine. n SUBSTANCE: invention refers to experimental medicine and medical microbiology. Guinea pigs are injected abdominally with dexamethasone at dose of 0.8 mg/kg once daily for 3 days. Two days after the last injection, the animal is injected intratesticularly with an excitatory culture in a sublethal dose of 100 million live microbes. n EFFECT: method enables developing certain manifestations of an infectious process, the use of which is necessary to solve a number of practical problems associated with assessing the pathogenic properties of microbes, animating laboratory cultures, assessing the effectiveness of therapeutic agents and prevention. n 1 cl, 6 tbl, 5 ex
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