| abstract |
FIELD: biotechnology. n SUBSTANCE: present invention relates to biotechnology, more specifically to a composition of a stabilized single-stranded nucleic acid molecule, which can be used in medicine as an inhibitor of TGF-beta1 gene expression, as well as in preventing or treating pulmonary fibrosis or acute lung injury. Content of the nucleic acid molecule after storage at 25 °C, relative humidity of 60 % for 4 weeks is not less than 80 % relative to content at the moment of storage start. n EFFECT: invention enables to stabilize a nucleic acid molecule consisting of nucleotide sequence SEQ ID NO: 1, at ambient temperature in range of pH from 4,6 to 6,5. n 19 cl, 23 dwg, 18 tbl, 9 ex |