http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2713400-C9
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14687eb1d34a9a00bd12725a2e42d611 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C55-07 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-60 |
| filingDate | 2018-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c69b2f56b0e5e3143c5c0243c02c762d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_826988d5b02c219e0e722b5c12f4ca95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8530699a30c60cdd7ccb53e07f297f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39903f7e64f07e6483356eb190f7e4a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12d1810ab414288ce82be96cca89cbbc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8937c75ae2af5e0d009810ed8bb7c04e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_128edcfb81fe388985361c06461b60b3 |
| publicationDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2713400-C9 |
| titleOfInvention | Method of producing 5r-[(benzyloxy)amino]piperidine-2s-carboxylate and oxalates thereof |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to methods of producing 5R-[(benzyloxy)amino]piperidine-2S-carboxylate and its oxalate, where L-glutamic acid or sodium salt of L-glutamic acid as a starting material is reacted with monochloroacetic acid under alkaline conditions by a substitution reaction to obtain N-carboxymethyl-L-glutamic acid (compound III), then compound III is reacted with an alcohol in the presence of an acid reagent through an esterification reaction to obtain a diester of N-alkoxycarbonylmethyl-L-glutamic acid (compound IV), under action of a strong base, compound IV is subjected to intramolecular condensation to form a ring, hydrolysis with decarboxylation and esterification to obtain piperidin-5-one-2S-carboxylate (compound V), compound V is condensed with a hydrochloride salt of benzyloxyamine in the presence of an alkali to obtain 5-[(benzyloxy)imino]piperidine-2S-carboxylate (compound VI), compound VI is subjected to reduction and chiral separation to obtain 5R-[(benzyloxy)amino]piperidine-2S-carboxylate (IIb) oxalate, which is then neutralized to obtain 5R-[(benzyloxy)amino] piperidine-2S-carboxylate (IIa). Obtained 5R-[(benzyloxy)amino]piperidine-2S-carboxylate (IIa) or oxalate 5R-[(benzyloxy)amino]piperidine-2S-carboxylate (IIb) is used to obtain avibactam (I). n EFFECT: use of an inexpensive and readily available starting material which is characterized by high selectivity and is environmentally friendly and environmentally friendly during the production process. n 10 cl, 3 dwg, 17 ex |
| priorityDate | 2017-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 197.