http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2713374-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b93da224b82da66d6bf34fa6484b1fe5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-743 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-84 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74 |
| filingDate | 2018-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ce6bd2e5c62a0d4a08af8c558b1f32b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_184e22d3bdc67b280cbd05fc488d3b74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c75e971f17234e0b8ccbfadad57db1c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4128b79a4caaafa1b4c8db0501dcb99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3d762d44af100e47fdc36bbf64de4b8 |
| publicationDate | 2020-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2713374-C1 |
| titleOfInvention | Method for prediction of androgenic alopecia in males |
| abstract | FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to dermatology and cosmetology, and can be used for prediction of androgenic alopecia in males by examining genetic predisposition to development of this disease and determining pathogenetically significant non-genetic indicators. A marker of the genetic predisposition is the single nucleotide polymorphism rs929626 in the EBF1 gene. Non-genetic blood plasma values are concentrations of total testosterone, dihydrotestosterone, copper, selenium, vitamin D and glucose. That is used to assess the probability of alopecia onset and progression with achievement of a certain stage of the disease according to Norwood-Hamilton classification by values of classification functions of linear discriminant analysis: F=A×2.5385+A×0.1143+A×0.0053+A×1.3781+A×23.6958+A×0.3191+A×16.0517-74.1424; F=A×7.1999+A×-0.0708+A×0.0058+A×0.4550+A×19.264+A×0.1182+A×18.0666-65.3727; F=A×3.9119+A×0.0425+A×0.0061+A×0.7940+A×21.1388+A×0.1906+A×15.8956-57.6115; F=A×3.9881+A×0.0874+A×0.0083+A×1.2447+A×15.9065+A×0.1867+A×16.8561-69.4355; F=A×3.9716+A×0.1348+A×0.0052+A×0.8559+A×25.3735+A×0.1884+A×13.2247-54.6796, where variables are: A– number of genotype of mononucleotide polymorphism rs929626 of allele variant G associated with predisposition to alopecia, namely AA=0, GA=1, GG=2; Ais blood plasma total testosterone concentration, nmol/l; Ais concentration of dihydrotetosterone in blood plasma, pg/ml; Ais copper concentration in blood plasma, mcmol/l; Ais selenium concentration in blood plasma, mcg/l; Ais concentration of vitamin D in blood plasma, ng/ml; Ais concentration of glucose in blood plasma, mmol/l. Thereafter, the onset and development of androgenic alopecia is predicted from the maximum value of the classification equation: Fabsence of risk of alopecia; F, F, Fand F– II, III, IV and V stage of alopecia, respectively.EFFECT: method provides prediction of androgenic alopecia in males due to integral assessment of the most informative markers of genetic predisposition and determination of a number of biochemical blood indices (hormones, microelements and vitamins) significant for progress and regress of the given disease.1 cl, 6 dwg, 1 tbl, 2 ex |
| priorityDate | 2018-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 191.