| abstract |
FIELD: chemistry.SUBSTANCE: invention relates to benzazepine dicarboxamide compounds of formula I, where Ris C-alkyl, Ris selected from a group consisting of C-alkyl, hydroxy-C-alkyl, C-alkynyl, amino-C-alkoxy-C-alkyl, amino-C-alkoxy-C-alkoxy-C-alkyl, halogen-C-alkyl, C-cycloalkyl-C-alkyl and phenyl-C-alkyl, where phenyl is substituted with amino-C-alkyl; Ris hydrogen; Ris selected from a group consisting of: phenyl, where phenyl is unsubstituted or substituted with one or two groups selected from a group consisting of C-alkyl, halogen, halogen-C-alkyl, C-alkoxy, amino-C-alkyl, amino-C-alkoxy-C-alkoxy, amino-C-alkoxy-C-alkoxy-C-alkyl, C-alkylsulphonyl and pyrrolidinylcarbonyl or heteroaryl, where heteroaryl is 5- or 6-membered aromatic ring containing one, two or three heteroatoms selected from N, O or S, and is unsubstituted or substituted with one or two groups selected from the group consisting of C-alkyl, halogen, C-alkoxy, hydroxy-C-alkyl, amino-C-alkyl, C-alkyl-amino-C-alkyl, di-C-alkyl-amino-C-alkyl, amino-C-alkenyl, amino-C-alkynyl, benzyloxycarbonylamino-C-alkyl, amino-C-alkoxy, pyrrolidinylcarbonyl and phenyl-C-alkyl, where phenyl is unsubstituted or substituted with C-alkoxy or amino-C-alkyl. Invention also relates to a method for preparing said compounds and a pharmaceutical composition possessing TLR agonist activity based thereon.EFFECT: technical result is obtaining novel compounds and a pharmaceutical composition based thereon, which can be used in medicine as drugs for treating diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, transplant rejection, graft versus host disease, immunodeficiencies and infectious diseases.17 cl, 80 ex |