abstract |
FIELD: medicine.SUBSTANCE: present invention relates to immunology. Disclosed are an isolated nucleic acid molecule encoding an anti-CD19 chimeric antigen receptor, an isolated anti-CD19 chimeric antigen receptor molecule, as well as a humanized anti-CD19-binding domain. Invention also discloses a vector, cells, a method for producing a cell, a method of producing a population of cells, a method for creating antitumour immunity and a method of treating. Described nucleic acid molecules encoding anti-CD19 CAR are also described.EFFECT: present invention can find further application in therapy of various proliferative diseases associated with expression of CD19, particularly cancer.83 cl, 12 dwg, 6 tbl, 6 ex |