| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a novel compound of formula (2) and variants thereof, which are FLT3 receptor antagonists. In general structural formula (2) n n n n X is CONH or triazolyl; Y is SO 2 , Q is selected from a group of formulas: n and , n where Q 1 and Q 2 are CH; Q 3 is selected from O, S, N and NH; Q 4 is selected from C, N and CO; Q 5 is selected from C and N; R 6 is selected from H, OH, alkyl, hydroxyalkyl and alkoxy, R 1 is OH; R 2 is H; R 3 is selected from H, OR 11 , halogen and O-(CH 2 ) p -O-alkyl; R 4 is selected from H, alkyl, halogen, CN, trifluoromethyl, CO-alkyl, phenyl and benzyl; provided that one of R 3 and R 4 is H; R 5 is H; two of R 2 and R 3 , or R 3 and R 4 , or R 4 and R 5 together with carbon atoms, to which they are bonded, form an aromatic ring containing 5–6 members, and the rest of R 2 -R 5 are H, R 7 and R 8 are alkyl or R 7 and R 8 together with atom N, to which they are attached, form group of formulas: n , or , n where R 10 is selected from H, alkyl, halogen, trifluoromethyl, aryl and hydroxyalkyl, or two adjacent groups R 10 together with ring atoms, to which they are bonded, form an aryl group; or R 7 and R 8 together with atom N, to which they are attached form group of formula , where Z is a group NR 14 , where R 14 is selected from phenyl, benzyl and pyrimidyl, or R 7 is H and R 8 is cycloalkyl, preferably cyclohexyl and adamantyl, R 11 is H or alkyl; R 15 represents a group selected from H, halogen, OH and alkoxy; s is 0, 1, 2 or 3; n is 1 with the exception of N-(5-chloro-2-hydroxyphenyl)-3-(piperidin-1-sulphonyl) benzamide. Invention also relates to versions of the compound of formula (2) - compounds (1), (2a), (2b), (2c) and (2d) and to a group of specific compounds which are described in the patent claim. n EFFECT: inventions can be used for treating pain disorders, pain disorders are selected from neuropathic pain, iatrogenic pain, including cancer pain, infectious pain, including herpetic pain, central pain, nociceptive pain, including postoperative pain, and back pain and orofacial area. n 13 cl, 1 tbl, 13 ex |