http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2709777-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9008466a40998f8be8e54cd3aceb10a2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2202-064 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M16-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M15-009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 2016-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4811ffcec7af119b455149fb2e074d32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_906b145a2046a373f4a633e200081c75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e749e265e27cc607d0a5cea214d72619 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6a99afd480d6a4e8e2e8c7031e949fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d2eb3616a4260b3cd3ca4a573481539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_443f4338bc243f8fa77b0159c515f94b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87b542b6db674876405941d2f59fc7ad |
| publicationDate | 2019-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2709777-C2 |
| titleOfInvention | Compounds having muscarinic receptor agonist and beta-2-adrenergic receptor agonist activity |
| abstract | FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and specifically to a compound of formula Iand pharmaceutically acceptable salts and solvates thereof. In the compounds of formula I: Y is selected from Y2 and Y1, which are divalent groups of formulaor, where Aand Aindependently absent or selected from a group consisting of (C-C)alkylene, (C-C)cycloalkylene; B is absent or selected from a group consisting of phenylene, optionally substituted with one group selected (C-C)alkoxy; C is absent or selected from a group consisting of -O-, -N(R) - or represents one of the following groups C1-C2, where Rin each case independently represents H or is selected from a group consisting of a straight or branched (C-C)alkyl, (C-C)cycloalkyl, phenyl, phenyl(C-C)alkyl, (C-C)alkylcarbonyl, (C-C)cycloalkylcarbonyl, phenylcarbonyl, (C-C)alkoxycarbonyl, (C-C)alkylaminocarbonyl, (C-C)alkylsulphanyl and phenylsulphonyl; and where Rcan optionally be further substituted with one group selected from halogen, -CN, (C-C)alkyl, halogen (C-C)alkyl, phenyl, phenyl (C-C)alkyl, (C-C)alkoxy, phenyl(C-C)alkoxy, (C-C)cycloalkyl, which is a saturated monocyclic group, D is absent or is selected from a group consisting of (C-C)alkylene and phenylene; n, n', n'' and n''' in each case independently equal to 0 or integer from 1 to 3; E is absent or is selected from -O-, -NR-, -NR-C(O)-, -C(O)-NR-; G is absent or is phenylene or thienylene, optionally substituted with one or two substitutes selected from a group consisting of halogen atoms, (C-C)alkyl, phenyl, halophenyl, thienyl and (C-C)alkoxy; L is absent or is a divalent group selected from -C(O)-, (C-C)alkylcarbonylen and (C-C) alkenylcarbonylene; i is 1 or 2; i' is equal to 1 or 2; Rin each case is independently selected from hydrogen and halogen; s is equal to 0. Also disclosed are a pharmaceutical composition, use of the compound of formula I and a device.EFFECT: technical result is obtaining novel compounds acting as both muscarinic receptor antagonists and beta-2-adrenergic receptor agonists.14 cl, 2 tbl, 31 ex |
| priorityDate | 2015-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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