abstract |
FIELD: medicine.SUBSTANCE: present invention relates to immunology. Disclosed is a binding domain against EGFRvIII, comprising a chimeric antigenic receptor encoding nucleic acids, a vector, a cell, as well as use of said inventions in the manufacture of a medicament, methods of producing a cell and obtaining a population of cells, a method for providing immunity, a method of treating.EFFECT: present invention can find further application in therapy using adaptive cell transfer.103 cl, 18 dwg, 9 ex, 2 tbl |