http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2704823-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a6f7331d2b03dab8b63878d3417605ee |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2037-0007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2017-22008 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M37-0092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N7-00 |
| filingDate | 2016-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7100d856805ede6e1c6c5667803cdf0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b794482c6951a85cc4f5041e0ce80ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df3e0a6efd4649adb9bbd64cc6b7498b |
| publicationDate | 2019-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2704823-C2 |
| titleOfInvention | Cavitation nucleus for drug delivery and method for drug delivery using same |
| abstract | FIELD: medicine; chemistry.SUBSTANCE: invention refers to drug delivery technology. Described is a cavitation embryo to cause cavitation to create a cavity near an epidermis of a living body, comprising: a shell which forms its outer surface to maintain its outer shape in the liquid; and a core which is located inside the shell and which determines the buoyancy of the cavitation nucleus in the liquid, wherein the cavitation nucleating cavity causes cavitation under the action of ultrasonic waves emitted into the liquid, wherein the core contains a perfluorocarbon-based gas, wherein the liquid is an aqueous solution containing a drug substance, and the cladding is formed by combining (i) at least one neutral phospholipid selected from a first group comprising DLPC (1,2-dilauryl-sn-glycero-3-phosphocholine), DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine), DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine), DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine), DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine), DMPE (1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine), DPPE (1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine), DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), and (ii) at least one negative polar phospholipid selected from a second group comprising DMPA-Na (1,2-dimiristoyl-sn-glycero-3-phosphate), DPPA-Na (1,2-dipalmitoyl-sn-glycero-3-phosphate), DOPA-Na (1,2-dileoyl-sn-glycero-3-phosphate), DMPG-Na (1,2-dimyristoyl-sn-glycero-3-phosphoglycerol), DPPG-Na (1,2-dipalmitoyl-sn-glycerol-3-phosphoglycerol), DOPG-Na (1,2-dioleoyl-sn-glycero-3-phosphoglycerol), DMPS-Na (1,2-dimiristoyl-sn-glycero-3-phosphoserine), DPPS-Na (1,2-dipalmitoyl-sn-glycero-3-phosphoserine), DOPS-Na (1,2-dioleoyl-sn-glycero-3-phosphoserine), DOPE-glutaryl-(Na)(1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), tetramyristoylcardiolipin-(Na), DSPE-mPEG-2000-Na (1,2-distearoyl-sn-glycero-3-phosphoethanolamine), DSPE-mPEG-5000-Na, DSPE-maleimide PEG-2000-Na and DOTAP-Cl (1,2-dioleoyl-3-trimethylammonium propane).EFFECT: technical result is providing cavitation nuclei, which can be moved to a position close to the epidermis, using gravity or electric field, maximizing the effect of drug delivery.19 cl, 12 dwg |
| priorityDate | 2015-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 108.