http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2704314-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_115e2d98d7c6b9b423621faa7484b58d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-06 |
| filingDate | 2018-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de2dff4a54826882ba3e8d5b27edce8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30d30a67678f399fff6e5c930e9c0d1c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ff8dc425042846d9b89444e7a538254 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bbf7637a9e5c3f0b465d5b7c4eac9d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd31cca570dce63c4332ebb7667775ef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eb488884909281cdbac982addcd71e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb91a7206a263150efb9325c0c9f424e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b47dceb7c21d2381295b99c2359dfa6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5632448afe547009a0265d06b303c6f |
| publicationDate | 2019-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2704314-C1 |
| titleOfInvention | Method for making small-diameter blood vessel prostheses by electrospinning and device for its implementation |
| abstract | FIELD: medicine.SUBSTANCE: group of inventions refers to medicine, biotechnology and tissue engineering and can be used for making small-diameter blood vessel prostheses. Method for making small-diameter blood vessel prostheses by electrospinning involves preparing a polymer composition by dissolving the initial synthetic polymer in a solvent, mixing polymer solution with protein solution and conducting electrospinning by applying obtained polymer composition from electrode-spinneret to electrode-collector with variable diameter. Selected polymer is dissolved in a suitable solvent to a final concentration of 3.0–10.0 % in the finished polymer composition, protein – to a final concentration of 0.1–30.0 % of the initial polymer weight, anticoagulant – to a final concentration of 0.5–1.5 % of initial polymer weight, then obtained solutions are mixed, polymer composition is placed in electrode-draw plate, before beginning of electrospinning, electrode collector diameter is set to 1.1÷1.4 times greater than the initial diameter of the collector by injecting an electrolyte therein and starting the electrospinning process with a program for smooth linear reduction of the diameter of the electrode collector to the initial diameter. Electrode-collector used is a steel tube with holes, on which a tube from electroconductive elastomer is fixed, and obtained vessel prosthesis is treated with bifunctional cross-linking reagent with subsequent deactivation of reactive groups by treatment with an alkaline glycine solution and dried. Device for conducting electrospinning is also disclosed.EFFECT: group of inventions provides preparing prostheses of blood vessels with high compliance and smooth inner surface, high hemo- and biocompatibility and longer life.12 cl, 11 dwg, 2 tbl, 3 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2797632-C1 |
| priorityDate | 2018-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.