| abstract |
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I), or a pharmaceutically acceptable salt thereof, where X is O or S; dotted line denotes double chemical bond; Ris lower alkyl, which optionally has one substitute selected from group G, Ccycloalkyl, or -low alkylene-(Ccycloalkyl); Rand Rare identical or different from each other and represent H or lower alkyl; Ris -low alkylene-X-lower alkyl, -lower alkylene-X-lower alkylene-Ccycloalkyl, -lower alkylene-Ccycloalkyl, or -low alkylene-X-Ccycloalkyl; Xis O or S(O), where n is 0, 1 or 2; Ris OH, NHor -O-lower alkyl, and Ris H; or Rand Rare linked to form together with -C(=O)-CO-, to which they are attached, 2,2-di(lower alkyl)-4-oxo-1,3-dioxolane-5,5-diyl; group Gconsists of halogen and OH. Invention also relates to a pharmaceutical composition based on the compound of formula (I), use of the compound of formula (I) and a method of treating nocturia.(I).EFFECT: technical result is obtaining novel heterocyclic compounds useful for inhibiting P-LAP.19 cl, 21 tbl, 27 ex |