| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d584042a524740a406723fe1631e49e5 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B6-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K103-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B6-03 |
| filingDate |
2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02b733591306b04382eb874bc0dfc6ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74df1d683269693005e99f0ad9649c65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79d0986f88c4cc1401ca4ab4cfa6b7fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6259bcf241d66abca71a54bd87db256c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2c7bc0e73ea5214190c885e0dd64ab9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acf460ef4b9451adce7e4e3020bdc501
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e6f7855cc6bd9e5c308d7e5983a4802
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c8dadd73680a5492e0887dd1058148b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eb6bb40d2977c33083b568ca1623ae6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09611616bb4f97d11d5199e6d3bfa15c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b587dfb8d2c6a87d6d90673069ed29d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4798285530dbe0e17c57ea1c7f32b791
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e297bb69e0b9450d0edf0c94bdda3d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d0b5702bc09963f2d1d424fa060a78e |
| publicationDate |
2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2700109-C1 |
| titleOfInvention |
Method for radionuclidean diagnostics of secondary edematous-infiltrative form of breast cancer with overexpression of her2/neu using recombinant address molecules darpin9_29 |
| abstract |
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to oncology and radionuclide diagnostics, and can be used for radionuclide diagnostics of secondary edematous-infiltrative form of breast cancer with Her2/neu overexpression using recombinant address molecules DARPin9_29. Injection form of the radiopharmaceutical is introduced on the basis of technetium-99m labeled recombinant address molecules DARPin9_29, which is prepared immediately before administration. For this purpose in aseptic conditions 1 ml of eluateTcO7 GBq by means of syringe is added to set for preparation of tricarbonyl technetium and incubated at temperature 100 °C for 30 minutes. After incubation, 1,000 mcl of technetium tricarbonyl is added to 334 mcl of DARPin9_29 at a concentration of the basic substance solution of 3.6 mg/l and incubated at temperature of 40 °C for 60 minutes. Further, the obtained compound is purified from protein impurities and non-technetium-bound DARPin9_29 molecules by means of cleaning columns. Preparation produced after cleansing in dose of 500 MBK is diluted in 10 ml of normal saline and slowly introduced into the patient through a sterilizing filter. In 4 hours after administration of the preparation, a single-photon emission computed tomography is performed on a two-detector gamma camera. Obtained results are evaluated and the malignant tumor is diagnosed when visualizing the RFP fixation in the mammary gland tissues.EFFECT: higher specificity and informativity and availability of a diagnostic technique for a secondary edematous-infiltrative form of breast cancer with Her2/neu overexpression.1 cl, 1 dwg, 1 ex |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2762317-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-218690-U1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2800818-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2737996-C1 |
| priorityDate |
2019-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |