| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2431238915fbf1b95c9d8f5ce8c14c2f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
| filingDate |
2018-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dedea72ceb33b3d04d3770e0205f3ed6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d8a3b20837260ce62d4029f8df215d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcb0968f3009a126095ee326e92f4e53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_376e001be5f3f689ebf382e3cb54bdfc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_106073918abf5852e0afcb1e63924467
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86ac74d1b540e8a0790aaec71b1616d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f64ab0182552912e0b868ff8500a142 |
| publicationDate |
2019-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2700097-C1 |
| titleOfInvention |
Dna-aptamer binding an extracellular domain of egfr |
| abstract |
FIELD: biotechnology.SUBSTANCE: described is a group of inventions comprising an aptamer DNA oligonucleotide specifically binding to EGFR, characterized by a nucleotide sequence: ACGCACCATTTGTTTAATATGTTTTTTAATTCCCCTTGTGGTGTGT, and a method of producing said aptamer DNA oligonucleotide. Method of producing DNA oligonucleotide involves cutting 5'- and 3'-end sequence of sequence ATCCAGAGTGACGCAGCATTTGTTTAATATGTTTTTTAATTCCCCTTGTGGTGTGTTGTGGACACGGTGGCTTAGT and 16G replacement by 16C, which leads to duplex increase from 5 to 8 nucleotide pairs and its stabilization.EFFECT: disclosed invention extends the range of agents for binding with EGFR.2 cl, 4 dwg, 2 ex |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2736790-C1 |
| priorityDate |
2018-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |