| abstract |
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where A is selected from,,,,;each of Tis independently selected from N, C(R); where Tare C(R) or one or two of Tare N, and the rest of Tare C(R); Tand Tare N; each of Tand Tare CH; each of Eis independently selected from N(CH); Lis a single bond; Lis selected from a single bond or C(=O)NH; Ris selected from H or methyl; Ris selected from H, methyl, F, Cl; Ris selected from H, methyl, trifluoromethyl, trifluoromethoxy, F, Cl, CN, methylaminocarbonyl, methylsulphonyl, morpholinylsulphonyl, 2-imidazolyl or dimethylamino; Qis selected from phenyl; where structural unitand B are selected from structures specified in claim 1. Invention also relates to specific compounds of formula (I).(I).EFFECT: technical result is obtaining novel heterocyclic compounds, useful as hedgehog pathway inhibitors, especially as SMO inhibitors and accordingly are effective in treating cancer.14 cl, 22 tbl |