| abstract |
FIELD: medicine. n SUBSTANCE: invention relates to medicine, in particular to a composition of long-release release goserelin acetate microspheres, as well as to use thereof for preparing a medicament for treating prostate cancer, premature puberty, adenomyosis, female infertility or hysteromyoma. Microspheres include goserelin, at least one poly(lactide-glycolide) and poloxamer or PEG. n EFFECT: implementation of the invention allows to obtain microspheres with prolonged release, which have relatively high bioavailability, which promotes complete manifestation of the drug action, and have a capture efficiency of more than 90 %. n 13 cl, 4 dwg, 6 tbl, 24 ex |