| abstract |
FIELD: medicine; pharmaceuticals. n SUBSTANCE: invention relates to compounds of formula (I), where values of R 1 –R 5 , X, Q and n are presented in the claim, which relate to modulators of protein functions, providing recovery of protein homeostasis, including activity of cytokines, Aiolos and/or Ikaros and intercellular adhesion. Also disclosed are pharmaceutical compositions containing said compounds, and use of compounds for treating or preventing diseases, disorders or conditions mediated by cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, uveitis, pulmonary inflammatory diseases, chronic obstructive pulmonary disease, Alzheimer's disease and cancer. n . n EFFECT: disclosed are protein-targeted compounds, their compositions, methods and uses aoolications. n 15 cl, 14 dwg, 1 ex |