| abstract |
FIELD: chemistry.SUBSTANCE: invention relates to a novel compound of formula (II), which has the properties of a cell proliferation inhibitor. Fabric or organ fibrosis is renal interstitial fibrosis, glomerulosclerosis, hepatic fibrosis, pneumosclerosis, IPF, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, skeletal muscle fibrosis, pancreatic fibrosis, hepatic cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, or vascular fibrosis. In formula (II),where each of Qand Qindependently represents N or CH; J is -O- or -(CH)-; Y is -O-, -(CH)-O-, -N(R) - or -(CH)-; where each is (CH)-O- and -(CH)- independently and optionally substituted with one or more substitutes independently selected from Calkyl, each Rindependently represents,where each E, Eand Eindependently represents N or CR; each T and Tindependently represents -NR-, -O-, -S- or -CRR-; each Rand Rindependently represents H; where each Rindependently and additionally substituted with one or more substituents independently selected from H, F, Cl, Br, I, Calkyl, Calkenyl, Calkoxy, Chaloalkyl, cyano, amino, Calkylamino, phenyl, and Chaloalkoxy; each Rindependently represents H or Calkyl; each Rindependently represents H; each Ris independently H, F, Cl, Br, or I; Ris methyl, ethyl, propyl, butyl, or tert-butyl; and each Ris independently H, F, Cl, Br, or I; each m is independently 1 or 2; and each n or p is independently 0, 1, 2, 3 or 4.EFFECT: compound can be used in preparing a medicinal agent for preventing, controlling, treating or relieving the severity of tissue or organ fibrosis.11 cl, 1 tbl, 69 ex |