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filingDate 2014-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2019-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2694056-C2
titleOfInvention Anti-tuberculosis stable pharmaceutical composition in form of dispersible tablet containing granulated isoniazid and granulated rifapentine, and method for preparing it
abstract FIELD: medicine; pharmaceuticals.SUBSTANCE: group of inventions refers to tuberculosis treatment. Oral fixed-dose pharmaceutical composition in the form of a dispersible tablet which dissolves in the liquid prior to administration includes isoniazid-containing granules and at least one intragranular excipient which contains microcrystalline cellulose, sodium starch glycolate, povidone or mixtures thereof; granules containing rifapentine and at least one intragranular excipient which contains microcrystalline cellulose, sodium ascorbate, sodium starch glycolate, hydroxypropyl cellulose, gelatized starch or mixtures thereof; and at least one extragranular excipient which contains sodium ascorbate. Also disclosed is a method for preparing an oral pharmaceutical composition.EFFECT: group of inventions provides a chemically stable oral pharmaceutical composition.10 cl, 2 tbl, 2 ex
priorityDate 2013-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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