http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2692628-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68235a5e3014d64e15d3c31ce7860832 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
| filingDate | 2018-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96ad075cbbb3ee6636bfd9f6c2783301 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73dfe16d4a16cebcaec0844a16f364a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2e0816b8ced8fd4218b872af57e9e96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b33d3f91e7dd767af63068aed00d7684 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e1ea7a57eaf58defaea8562bd0ffcd7 |
| publicationDate | 2019-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2692628-C1 |
| titleOfInvention | RECOMBINANT VARIOLOVACCINE VIRUS STRAIN VV-NS1-dGF PRODUCING NS1 PARVOVIRUS H-1 PROTEIN AND HAVING ONCOLYTIC ACTIVITY ON HUMAN GLIOBLASTOMA |
| abstract | FIELD: biotechnology. n SUBSTANCE: invention relates to biotechnology and specifically to a recombinant variolovaccine virus (VVV) strain producing apoptosis-inducing oncotoxic NS1 protein of rat parvovirus H-1 and having oncolytic activity on human glioblastoma. VV-NS1-dGF strain is deposited in the State collection of virus infectious agents and rickettsiosis of FBIS State Research Center of Virology and Biotechnology Vector of Federal Service for Supervision of Consumer Rights and Human Welfare, No. V-803. Recombinant strain VV-NS1-dGF is produced on the basis of strain L-IVP of a variolovaccine virus containing deletion of a gene fragment of a viral growth factor, in area of which there is a synthetic NS1 gene of rat parvovirus H-1. NS1 gene is expressed under the control of an early-late synthetic promoter PE/L VVV to produce a protein with a molecular weight of 100 kDa. n EFFECT: invention widens the range of products for developing new-generation drugs for combating oncological diseases. n 1 cl, 6 dwg, 5 ex |
| priorityDate | 2018-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.