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filingDate 2018-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e03ff8a8d6784c8f6788104b53f7cd16
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publicationDate 2019-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2689782-C1
titleOfInvention Method of producing double-layer barrier membrane for directed bone regeneration
abstract FIELD: medicine. n SUBSTANCE: invention refers to regenerative medicine and dentistry, and can be used for directed bone regeneration in osteoplastic surgeries. Method involves production of a two-layer barrier membrane with a different area of layers and a hydrophilic porous chitosan inner layer. For this purpose, preliminarily a hydrophilic porous chitosan layer with thickness of 1 mm and area of 10 × 10 mm 2 is obtained from chitosan 3 % solution. Then, an external hydrophobic layer is obtained by dissolving poly-L-lactide-glycolide in chloroform to a final solution concentration of 3 mg/ml and applying it in a uniform layer on a cover glass with size of 25 × 25 mm 2 . Further, the layers are glued by applying a porous chitosan layer to the centre of the cover glass with the polymer solution. Obtained two-layer membrane is air-dried, detached from glass and sterilized by ozone. n EFFECT: presented invention allows improving efficiency of double-layer barrier membrane structure, and also simplifying and cheapening the method of producing a double-layer barrier membrane for directed bone regeneration. n 4 cl, 3 ex, 2 tbl, 3 dwg
priorityDate 2018-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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