http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2688349-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-168 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J20-32 |
| filingDate | 2015-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e6e809d0acb7cab9db0b1abe2d018c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f65054a45344989233dedb95d786591 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fffb0a7947d4789dac8c8a58094f9bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a80db5d09ab1217bea0931a9ec3c352a |
| publicationDate | 2019-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2688349-C2 |
| titleOfInvention | In vitro prediction of antibody half-life in vivo |
| abstract | FIELD: biotechnology. n SUBSTANCE: method comprises the following steps: a) determining the retention time of the antibody and the control antibody on a FcRn-based affinity chromatography column with elution with a positive linear pH gradient in presence of 50 mM to 200 mM sodium chloride; b) determining the retention time of the antibody and the control antibody on a FcRn-based affinity chromatography column with elution with a positive linear pH gradient in presence of 300 mM to 600 mM sodium chloride. Antibody with an increased half-life in vivo relative to the control antibody is selected from an antibody which has a retention time determined at step a) which is at least 5 % greater than the retention time of the control antibody determined at step a), and retention time determined at step a), which is within 5 % of retention time determined at step b). Antibody with reduced half-life in vivo relative to the control antibody is selected from an antibody which has a retention time defined at step a) which is at least 5 % less than the retention time of the control antibody determined at step a), and retention time determined at step a), which is within 5 % of retention time determined at step b). n EFFECT: disclosed is a method of selecting an antibody with an increased or reduced half-life in vivo relative to a full-length control antibody. n 21 cl, 28 tbl, 11 ex |
| priorityDate | 2014-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.