http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2684289-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d584042a524740a406723fe1631e49e5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2018-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fdb5929594953ec2f3ef4935951dd86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37f0481b09865035e1b1559b684ab946 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52294b558e0cc1f8d42e82f44dbd98f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e620b1445a52f7f4cbc9314e292167c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e6f7855cc6bd9e5c308d7e5983a4802 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4798285530dbe0e17c57ea1c7f32b791 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02b733591306b04382eb874bc0dfc6ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_879426b675d83dcb6321ed5e872beff2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d0b5702bc09963f2d1d424fa060a78e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fd73c5a30cf350ef06cf70dfa09f811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c8dadd73680a5492e0887dd1058148b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79d0986f88c4cc1401ca4ab4cfa6b7fe |
| publicationDate | 2019-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2684289-C1 |
| titleOfInvention | METHOD FOR OBTAINING COMPLEX OF TECHNETIUM-99m WITH RECOMBINANT PROTEIN-TARGETED MOLECULES FOR RADIONUCLIDE DIAGNOSIS OF ONCOLOGICAL DISEASES WITH HER-2/neu OVEREXPRESSION |
| abstract | FIELD: medicine. n SUBSTANCE: invention refers to medicine, oncology and chemical engineering. Method of producing the technetium-99m complex with recombinant protein-targeted molecules for radionuclide diagnosis of oncological diseases with HER-2/neu overexpression consists in the fact, that at the first stage aquacarbonyl technetium-99m [ 99m Tc(H 2 O) 3 (CO) 3 ] + is obtained, using sodium tetraborate sodium lyophilizate, decahydrate, sodium carbonate, disodium boron carbonate, which can also contain potassium sodium tartrate tetrahydrate or sodium citrate monohydrate, then lyophilisate is added with 1–3 ml sodium pertechnetate solution, 99m Tc with activity of 0.74–3.7 GBq and heated in a boiling water bath for 20–30 minutes, cooled to room temperature and added with 1 M HCl to pH 7.4 or 300–900 mcl of 1 M sodium phosphate solution with pH 7.4, further, a chelating agent succinimid-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate (DPAH) is added to DARPin in a phosphate buffer with pH 8.3-8.5 to obtain DPAH-DARPin, then aqua-carbonyl technetium-99 m [ 99m Tc(H 2 O) 3 (CO) 3 ] + is bound with DARPin or DPAH-DARPin, for which to DARpin or DPAH-DARPin in amount of 100 mcg in a phosphate-buffer solution at pH 7.4 1 ml of aqua-carbonyl technetium-99m solution [ 99m Tc(H 2 O) 3 (CO) 3 ] + is added, then incubated at 40 °C for 30–60 minutes, purification is carried out by gel filtration on a column. n EFFECT: invention is aimed at radionuclide diagnosis of oncological diseases with HER-2/neu overexpression. n 1 cl, 12 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2737996-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2739107-C1 |
| priorityDate | 2018-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.