| abstract |
FIELD: medicine; pharmaceuticals. n SUBSTANCE: disclosed is a colon-specific delayed-release pharmaceutical composition. Pharmaceutical composition comprises a) a monolithic matrix core comprising hydroxypropyl methylcellulose, wherein ground or micronised menthol is dispersed, wherein the mass ratio of menthol to hydroxypropyl methylcellulose is in the range from 1:5 to 4:1, and b) gastro-resistant core coating (a). Core can comprise only one hydroxypropyl methylcellulose, having an effective viscosity at 20 °C in 2 % aqueous solution in the range from 80 to 120 MPa·s or a mixture of at least two hydroxypropyl methylcelluloses with different effective viscosities. According to the invention, the composition is used for treating irritable bowel syndrome. n EFFECT: according to the invention, the pharmaceutical composition provides a menthol release profile for 24 hours. n 13 cl, 5 ex |