| abstract |
FIELD: chemistry.SUBSTANCE: invention relates to the field of organic chemistry, namely to a heterocyclic compound of formula (IIB) or to its pharmaceutically acceptable salt, where E represents -CH- or-CH(CH)-; Q represents -CH-; Z is hydrogen; V represents C-Ror N; Ris hydrogen; Rrepresents a difluoromethoxy group; Rrepresents hydrogen, halogen or C-C-alkyl; R is hydroxy (C-C)alkyl or (C-C)alkylsulfoxyminyl; or Rrepresents cyclobutyl, this group may optionally contain 1, 2 or 3 substituents independently selected from C-C-alkyl and hydroxy groups; Ris hydrogen; and Ris hydrogen. Also the invention relates to a pharmaceutical composition based on a compound of formula (IIB), its use and a method for the treatment of rheumatoid arthritis or Crohn's disease..EFFECT: new heterocyclic compounds with the properties of the modulator of TNFα activity have been obtained.9 cl, 13 ex |