| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a compound having the structure of formula (II), or a pharmaceutically acceptable salt thereof, which have the property of inhibiting histone deacetylase (HDAC) enzymes. In formula (II), R A is H or F; R C is H, Cl or F; Het is selected from oxetanyl, piperidinyl and 8-azabicyclo[3.2.1]octanyl, and if Het is piperidinyl or 8-azabicyclo[3.2.1]octanyl, then the nitrogen atom in the ring is substituted with R B ; R B is CH 3 , CH 2 C(CH 3 ) 3 , CH 2 C(OH)(CH 3 ) 2 or CH 2 cyclopropyl. (II). n EFFECT: invention also relates to particular compounds selected from said group, a pharmaceutical composition and the use of compounds for the preparation of a medicament for the treatment or prevention of a disease or condition associated with HDAC inhibition. n 18 cl, 1 dwg, 4 tbl, 13 ex |