http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2673452-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8251e39cb0aea08bdf5059517a5771ba |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-502 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-502 |
| filingDate | 2017-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d48c93124eb1afcaf60f242977a9aa98 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0812a1fd41f5af129e138011e0ee3b18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_521f4982f140e9e7f3f744e683e60b33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afe907c97c914a720fcdefbea0e052fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d9204a80fd5477f674ec0427dbc50a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fa3241ecaa4874574ca1961f2c551ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f03530ca857eb5aea905c9dbd428e11 |
| publicationDate | 2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2673452-C1 |
| titleOfInvention | Method of obtaining active pharmaceutical substance, presenting aminodihydrophthalazinedione of sodium |
| abstract | FIELD: medicine; pharmaceuticals. n SUBSTANCE: invention relates to a method for producing an active pharmaceutical substance based on the sodium salt of 5-amino-2,3-dihydro-1,4-phthalazinedione (sodium aminodihydrophthalazalindione). Essence of the method consists in: adding an equivalent amount of a 30 % aqueous solution of sodium alkali to a suspension of luminol in 3 volumes of distilled water, dropwise during cooling, mixing for 2–3 hours until almost complete dissolution, then filtering. Adding 10-fold amount of isopropyl alcohol to the filtrate, cooling to minus 5 °C and re-filtering. Drying. After drying, crystals are obtained which are associates of the hydrated forms of the luminol sodium salt. Resulting crystals are dissolved in water for injection, and then filtered through a filter, containing filtering layers of polyethersulfone membranes with a pore size of 0.2 microns. Resulting sterile solution is rapidly cooled to a temperature of minus 25 ± 10 °C and placed in a freeze drying unit. Sterile sodium-aminodihydrophthalazinedione drug is obtained at the end of this process, which is used as an active pharmaceutical substance. n EFFECT: technical results is to increase the stability of technological parameters, the representativeness of the obtained substance, minimization of harmful impurities (isomeric micro impurities such as N-aminoisomer and linear sodium oligomers), environmental safety of the process. n 1 cl, 4 dwg, 1 tbl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2760262-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2744858-C1 |
| priorityDate | 2017-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.