| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to organic chemistry, specifically to a heterocyclic compound of formula (I), wherein W 1 is N or CR C ; W 2 and W 3 are CR C ; Z is CN or ; X is H, (C 1 -C 6 )alkyl, wherein (C 1 -C 6 )alkyl is optionally substituted with 1 substituent independently selected from OR a ; Y is (C 3 -C 6 )cycloalkyl or (C 6 -C 10 )aryl, where each (C 6 -C 10 )aryl is substituted with 2 substituents selected from F; R 1 is Cl or OR a ; each R a independently is H or (C 1 -C 6 )alkyl; and each R c is independently H. Also, the invention relates to a pharmaceutical composition based on a compound of formula . n EFFECT: technical result is obtaining novel heterocyclic compounds which modulate the activity of tyrosine kinase, which is phosphatidylinositol 3-kinase (PI3K) and MPM (mTOR) and are useful in the treatment of proliferative diseases. n 8 cl, 8 tbl, 15 ex |