http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2670762-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b1013f5c30c00d25c17de37a3ae1ca59 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5386 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08 |
| filingDate | 2014-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee1d8ce64b283eb877f8d585ff1a6e79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ce380b07829e95be5fb8df0da60083b |
| publicationDate | 2018-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2670762-C2 |
| titleOfInvention | Derivatives of 6- (pyrimidinoamino-pyridine) benzoimidazole, useful for the treatment of cancer |
| abstract | The invention relates to the field of organic chemistry, namely to the derivatives of 6- (pyrimidinoaminopyridine) benzoimidazole of formula (I ') or its stereoisomer, where A 1 and A 2 are independently selected from nitrogen; R 1 is selected from C 1-6 alkyl; R 2 is selected from C 1-6 alkyl; R 3 and R 5 are independently selected from halogen; R 4 is selected from a nitrogen-containing 5-6-membered heterocyclyl, optionally substituted with Q 2 , where the nitrogen-containing 5-6-membered heterocyclyl is a nitrogen-containing 5-6-membered heterocyclyl containing 1-2 nitrogen atoms; a nitrogen-containing 7-9-membered bridged heterocyclyl, optionally substituted with Q 2 , where the nitrogen-containing 7-9-membered bridging heterocyclyl is a nitrogen-containing 7-9-membered bridging heterocyclyl containing 1-2 nitrogen atoms; 6-10 membered fused heterocyclyl containing 1, 2 or 3 identical or different heteroatoms and optionally substituted with Q 2 , where the heteroatoms are selected from a nitrogen atom and an oxygen atom and contain at least one nitrogen atom; nitrogen-containing 7-11 membered spiroheterocyclyl, optionally substituted with Q 2 , where the nitrogen-containing 7-11 membered spiroheterocyclyl is a nitrogen containing 7-11 membered spiroheterocyclyl containing 1-2 nitrogen atoms; Q 2 is selected from amino or di-C 1-6 alkylamino; or from C 1-6 alkyl, 3 to 8-membered cycloalkyl, oxacylobutanil, nitrogen-containing 5-6-membered heterocyclyl or nitrogen-containing 8-membered bridged heterocyclyl, each of which is optionally substituted by a substituent, where the substituent is selected from C 1-6 alkyl and 3 -8 membered cycloalkyl; n is selected from 0, 1. Also, the invention relates to a pharmaceutical composition having the ability to inhibit the activity of CDK4 and / or CDK6 kinases, based on a compound of formula (I '). EFFECT: novel compounds useful for reducing or inhibiting the activity of CDK4 / 6 kinase in a cell, and / or in treating and / or preventing cancer-related diseases mediated by CDK4 / 6 kinase. 3 n. and 20 hp f-ly, 12 tab., 36, etc. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2732952-C2 |
| priorityDate | 2013-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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