| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to compounds of formula (I): n Formula (I) or a pharmaceutically acceptable salt thereof, where: Z is -O- or -S-; Y is - (CH 2 ) 3 -NR 9 R 10 ; R 1 is a partially unsaturated or aromatic 5- or 6-membered heterocycle; R 2 independently in each case is -F, -Cl, -Br, -CH 3 or -CN; R 3 independently in each case is -H,- F, -Cl, -Br, -CF 3 , -OCF 3 , -CN, (C 1 -C 12 )alkyl or (C 1 -C 12 )alkoxy; R 9 represents (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, pyrazolyl or pyridinyl; here R 9 optionally is further substituted with 1 or 2 substituents selected from the group consisting of -COOH, -COOR 11 , -CONR 11 R 12 , -SO 2 R 11 , -SO 2 NR 11 R 12 , -OH, -CN, -OR 11 and -NR 11 R 12 ; where R 11 and R 12 can form a 6-membered heterocycloalkyl ring; R 10 is R 11 , -COR 11 , -COOR 11 , -SO 2 R 11 , 5-methyl-2-oxo-1,3-dioxol-4-yl, , -COO-CH(CH 3 )OCOCH(CH 3 ) 2 ; or R 9 and R 10 together form a piperazinone or 4-8-membered heterocycloalkyl ring, wherein said heterocycloalkyl ring is substituted with 1 or 2 substituents selected from the group consisting of -COOH, -COOR 11 , -CH 2 -COOR 11 , -OH, -NH 2 , -CN and (C 1 -C 8 )alkoxy; R 11 and R 12 are independently H or (C 1 -C 6 )alkyl optionally substituted with 4-8-membered heterocycloalkyl ring; and m and n are each independently 1, 2, 3 or 4 modulating the sodium channels, in particular modulating NaV1.7. n EFFECT: modulators of the sodium channel for the treatment of pain are proposed. n 40 cl, 33 ex, 2 tbl |