http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2667892-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c6afb6d215a9eb80e63d6f9b24c04d2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4412 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b77fb23337c21938fb61f34435e811c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8b43d12d8717bc78e92cf6e3cb26a35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ad685747e401b37f8eb9228e8caef44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6df063b7b188ea97063258b4871987c4 |
| publicationDate | 2018-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2667892-C2 |
| titleOfInvention | Pyridyl ketone derivatives, method of preparing same and pharmaceutical application thereof |
| abstract | FIELD: medicine; pharmaceuticals. n SUBSTANCE: invention relates to pyridyl ketone derivatives of formula (I) or pharmaceutically acceptable salts thereof: where: R 1 is selected from the group consisting of phenyl and pyridyl, where independently of each other, each of phenyl and pyridyl is optionally substituted with one or more groups, selected from the group consisting of halogen, alkyl, haloalkyl, -OR 7 , -C(O)R 7 , -C(O)NHR 7 , -NHC(O)R 7 , -NHC(O)OR 7 and -NHS(O) m R 7 ; R 2 is hydrogen; R 3 is selected from the group consisting of hydrogen and alkyl, wherein alkyl is optionally substituted with one or more groups selected from the group consisting of -OR 7 ; R 4 is phenyl, where the phenyl is optionally substituted with one or more groups selected from the group consisting of halogen and alkyl; R 5 is selected from the group consisting of hydrogen and alkyl; R 6 is selected from the group consisting of hydrogen, halogen and alkyl; R 7 is selected from the group consisting of hydrogen, alkyl, C 3-6 cycloalkyl, 5- or 6-membered heterocyclyl, wherein, independently of each other, each of said radicals is optionally substituted with one or more groups selected from the group consisting of alkyl and halogen; wherein the heterocyclyl contains one or two heteroatoms selected from the group consisting of N, O and S(O) m ; independently of each other, each of the R 8 and R 9 is selected from the group consisting of hydrogen or alkyl; and m is 2, and use thereof as MEK inhibitors, and especially as therapeutic agents for the treatment of cancer. n EFFECT: disclosed are novel pyridone derivatives, preparation method thereof, pharmaceutical compositions containing the same, and their use as MEK inhibitors, and especially as therapeutic agents for cancer. n 12 cl,4 tbl, 33 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2704251-C2 |
| priorityDate | 2013-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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