| abstract |
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I) wherein n is 0; bond α is a single bond; ring A is an aromatic ring, where i) V and X represent N, W and Z represent CH and Y represent C; or ii) V, Y and Z represent N, W represents CH and X represents C; or iii) V, W and Y represent N, X represents C and Z represents CH; Rrepresents -CH-R, Rrepresents -C(O)Ror -C(OR)(R)(R), Rrepresents a hydrogen atom; each Rrepresents C-cycloalkyl or 6-membered heterocyclyl containing one nitrogen atom as a heteroatom, Ccycloalkyl is optionally substituted with two Rgroups; 6-membered heterocyclyl is optionally substituted by one Rgroup; each Rindependently represents a halogen atom or -C(O)N(R), and Ris a hydrogen atom; and each R independently represents a hydrogen atom or R, Ris phenyl, optionally substituted with C-alkyl group. Invention also relates to individual compounds and to a pharmaceutical composition..EFFECT: novel compounds of formula (I) having IDO/TDO inhibitory activity are obtained.18 cl, 4 dwg, 19 ex |