| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is -O- or -CH 2 -, n from 1 to 3, R 1 is -H, halogen or lower alkyl, R 2 and R 3 are each the same or different from each other and are -H, halogen, lower alkyl or halo-lower alkyl, R 4 is -Lk-NH-R 0 , Lk is lower alkylene or bond, R 0 is lowest alkyl, lower alkylene-OH or cycloalkyl, and R 5 is -H or lower alkyl. Invention also relates to a pharmaceutical composition having IK1 channel activating action. n (I). n EFFECT: obtained are novel compounds that can be used in medicine for the treatment of visceral pain, inflammatory pain, osteoarthritis pain, neuropathic pain or fibromyalgia. n 17 cl, 26 tbl, 31 ex |