http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2663727-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b760fbf53b253bf5d4ad37c73d816fb5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1793 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 |
| filingDate | 2014-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_284a2641310c25c534ab3b93d30e706d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb353328d3e30dd022ad22b15f6ef1a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06b4b94de9ba77ddd31314645ddf6917 |
| publicationDate | 2018-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2663727-C2 |
| titleOfInvention | Alternative compositions for tnfr:fc chimerical polypeptides |
| abstract | FIELD: biochemistry. n SUBSTANCE: group of inventions relates to biochemistry. Aqueous composition having an inhibitory effect on TNF (variants) is proposed. In a first embodiment, the aqueous composition comprises an isolated polypeptide, a salt in a concentration of 80 to 130 mM, an aqueous buffer at a concentration of 20–30 mM, and sucrose at a concentration of 34–80 mg/ml. In this composition, arginine and cysteine are not presented. In a second embodiment, the aqueous composition comprises an isolated polypeptide, a salt in a concentration of 80 to 130 mM, wherein the salt is not present at a concentration of 100 mM, a succinate buffer selected from trehalose and sucrose, or a combination thereof. No free amino acids are present in said composition. Isolated polypeptide in each composition is an extracellular ligand-binding part of the human p75 tumor necrosis factor receptor fused to the human IgG1 Fc domain. n EFFECT: invention provides an aqueous composition having high stability at high temperatures without arginine and cysteine. n 41 cl, 15 dwg |
| priorityDate | 2013-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 167.