http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2663718-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3dd0d68fdd587e233a26b35c676149db |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16134 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1018 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-11 |
| filingDate | 2011-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_676f3d355d092b383a5afc5d6e2f6c76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e4dd63d4173e5bee0b156ab9cf51301 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9bd59e818e13ad3ff29dd5870d9a42e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae94a1d149b6b5c3720ebc9125cd4c2c |
| publicationDate | 2018-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2663718-C2 |
| titleOfInvention | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| abstract | FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology, specifically to modified hemagglutinins (HA) of the influenza virus, and can be used in medicine for the preparation of a medicament for the treatment or prevention of infection caused by the H5 influenza virus. Modified H5 HA polypeptide that differs from the reference H5 HA polypeptide by at least substitutions of Q226L and / or G228S and includes a deletion at position 130, and preferably does not contain glycosylation at position 158, is obtained, wherein the numbering of amino acid positions is based on the canonical numbering system H3.EFFECT: invention makes it possible to obtain a modified HA polypeptide that competes for the glycan-HA polypeptide interaction between the glycan with an umbrella topology and the HA polypeptide and binds to human lung tissue, which, in turn, prevents the binding of H5 influenza virus particles to the subject's cell, and can be used in antiviral therapy.20 cl, 28 dwg, 1 tbl, 5 ex |
| priorityDate | 2010-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 483.