| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d10d868e99903c426feee661b799065f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 |
| filingDate |
2017-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f5ee5e6f95595a50e859b2fea5aebbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0db3cff3b427d60aa9eaaa7e6efc9f07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d15f09c6ed097d70d5d57511c1ce668
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bb10165a87396a3e1016c784cc9f342
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a25ebbc8b7cf6c5932261eb37f024cf2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e3276b501a687b181e7cb4ead0a57ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_151a6b7b95b384e0ebc5fac585995990
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e410e9c4b17c245d1175ec8342425b5e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7dd0b05655efd1978c7ca72031e40d3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab60063733256a8dcbc9daa54942d4e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f6ef1ef2ceae370b68f413d345201d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8702f1660b611d26667d939627784c6 |
| publicationDate |
2018-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2662354-C1 |
| titleOfInvention |
Method for treating oncological diseases |
| abstract |
FIELD: medicine. n SUBSTANCE: invention relates to medicine. Proposed is a method for treating oncological diseases. Initially, tumor cells are introduced into the primary culture and treated once with cross-linking cytostatic at a dose corresponding to 1/3 of the total single clinical dose of the cytostatic. Profile of the tumor cell reparative cycle in the patient is determined. Day of the synchronization in the sensitive G1/S phase of the cell cycle and the maximum accumulated number of stem initiating tumor cells of the tumor is determined. Number of stem initiating tumor cells and cell cycle distribution is determined daily by FACS analysis and cytologically by the TAMRA internalization of the labelled DNA-probe into these cells, on the basis of which the day of the maximum accumulation of TAMRA positive cells which corresponds to their synchronization in the therapy sensitive phase of the cell cycle is determined. Cytotoxic is administered four times by three treatments at the indicated doses. Double-stranded DNA preparation is administered four times after each injection of the cytostatic at a time point of demarcation at a dose of 10–20 mg per 1 kg of body weight, intraperitoneally or intramuscularly, or inside the tumor. n EFFECT: invention provides a wider application of the treatment method and higher treatment efficiency. n 1 cl, 1 tbl, 12 dwg |
| priorityDate |
2017-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |