http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2659214-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29540323725ed53830a134fae978c78d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2013-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d7e79ff5b3d837d2d25ec25b5e4ff05 |
| publicationDate | 2018-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2659214-C2 |
| titleOfInvention | Preparation of intermediates of x-ray contrast agents |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to a process for the preparation of iodinated X-ray contrast agents and, in particular, to the preparation of key intermediate compounds used for the preparation of iodinated X-ray contrast agents. Process for the preparation of an N-acylated monomeric compound selected from 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compounds A) and N,N'-bis(2,3-dihydroxypropyl)-5-formamido-2,4,6-triiodoisophthalamide (Compound C) includes a step of deacylating the acylated hydroxyl groups by adding Compound B2 to an aqueous solution of a deacylating agent which is an inorganic base. For compound B2, each of X is independently hydrogen or an acyl group, with the proviso that at least one of the X groups attached to the nitrogen atom is an acyl group. n EFFECT: method allows to obtain an optimal yield and to reduce formation of pollutants. n 6 cl, 2 ex |
| priorityDate | 2012-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.