http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2655727-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_659313dc2593fb2918b81d0ad7b3c72e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-541 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4355 |
| filingDate | 2014-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d2ce5260c2ddcc6c6b5fec05f2f4080 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1baf71037316da6007b3aaafea25bff4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e787abde36870cf1fb4ee695db3338d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bf01b8a8fb734492b2aa6a5c81facf9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e953c9e60e6afe99f796d9c268bf71a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_686a86ad7fe2e5a056f8b176e5b07c3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24990f50aa754b89a87e07925af43c4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f13c8d282df71e214ed701c7c8f4d203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a46214550d4856e0f58af8f65631f5c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cdeeb2fef0e96bd4f00166cc6371e8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3321e33a46670d60b5084b28fa10d1dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba1e237917a208285bfeddb101c74199 |
| publicationDate | 2018-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2655727-C2 |
| titleOfInvention | Furopyridines as bromodomain inhibitors |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to novel furopyridine derivatives of formula I n n n n where: V is N or C-R 2 ; W is N or C-R 8 ; X is N, CH or C(CH 3 ); Y is N or C-R 5 ; Z is N or C-R 15 ; Q is N or CH; R 1 is C 1-4 alkyl or deuterated C 1-4 alkyl; R 2 , when present, is H, OH, -NH 2 , -OC 1-4 alkyl, -NHC(O)H, -NHC(O)C 1-4 alkyl, -H(CH 3 )C(O)C 1-4 alkyl, -NHC(O)NH 2 , -NHC(O)C 1-4 alkyleneNH 2 , -N(CH 3 )C(O)NH 2 , -N(CH 3 )C(O)C 1-4 alkyleneNH 2 , -OC 2-4 alkyleneOCH 3 , -OC 2-4 alkyleneOH or R 2 is a group selected from -G-CH 2 CH(R 3 )(R 4 ), -G-CH(R 3 )(R 4 ) and -G-R 3 , in which G is NH, N(CH 3 ), O, C(O)NH or NHC(O); R 3 is phenyl, pyridinyl, C 3-7 cycloalkyl or a 5-6 membered heterocycle containing an oxygen or nitrogen atom and optionally substituted with =O; and R 4 is H or C 1-4 alkyl; R 5 , when present, is H, OH, -OC 1-4 alkyl, -CH 2 NH 2 , -OCF 3 , -C(O)NHC 1-4 alkyl or -CO 2 H; R 6 is -NR 11 R 12 or group n n n n D is CH or N; E is N, O, CH or SO 2 ; R 7 , when present, is H, OH, C 1-4 alkyl, -SO 2 C 1-4 alkyl, -NHSO 2 CH 3 , -C(O)C 1-4 alkyl; R 8 , when present, is H, C 1-4 alkyl, OH, -OC 1-4 alkyl, -OC 2-4 alkyleneOC 1-4 alkyl, -OCF 3; -OC 1-4 alkyleneF, -OC 1-4 alkyleneCHF 2 , -OC 2-4 alkyleneOH, -Ophenyl, -OC 1-4 alkylenephenyl, -NHC 3-7 cycloalkyl, -NHC 1-4 alkylene C 3-7 cycloalkyl, -OC 3-7 cycloalkyl, -OC 1-4 alkyleneC 3-7 cycloalkyl, -NHC 4-6 heterocycle, -NHC 1-4 alkyleneC 4-6 heterocycle, -OC 4-6 heterocycle or -OC 1-4 alkylene C 4-6 heterocycle, containing as a heteroatom N or O, where each C 3-7 cycloalkyl or C 4-6 heterocycle is optionally substituted with one or two substituents independently selected from halogen and oxo; or R 8 and R 2 together with the carbon atoms to which they are attached form a heterocycle containing as a heteroatom N and optionally substituted oxo; R 9 is H, C 1-4 alkyl, halogen, OH, -OC 1-4 alkyl, -CH 2 OH, -C(O)NHCH 3 , -C(O)NH(CH 3 ) 2 ; R 10 is H, C 1-4 alkyl, halogen, OH, -OC 1-4 alkyl or oxo; R 11 is H, C 1-4 alkyl or SO 2 CH 3 ; R 12 is H, C 1-4 alkyl, C 2-4 alkyleneNHR 13 , SO 2 CH 3 , a 5-6 membered heterocycle containing SO 2 ; R 13 is H or SO 2 CH 3 ; R 14 is H or C 1-4 alkyl; R 15 is H, C 1-4 alkyl or NHC(O)C 1-4 alkyl; R 16 is H or C 1-4 alkyl; and each of n and m is an integer independently selected from 0, 1 and 2; provided that no more than 2 of V, W, X, Y and Z are N; or salts thereof. n EFFECT: invention also relates to a pharmaceutical composition having bromodomain inhibitor activity, based on said compounds, use thereof in the manufacture of a medicament for use in the treatment of diseases or conditions, for which a bromodomain inhibitor is indicated, and a method of treating such diseases or conditions. n 18 cl, 2 tbl, 109 ex |
| priorityDate | 2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 782.